Antidepressants in naturopathy An antidepressant is a drug from the class of psychotropic drugs that is primarily used to treat depression. Antidepressants can also be used to treat a variety of other mental disorders. Herbal remedies for depression Antidepressants do not work for everyone and are not without side effects. However, there are other ways to treat depression that you could try first before resorting to strong weapons. In addition to specific nutritional supplements, herbal remedies for the psyche are also available. Medicinal plants have been proven to have a very good effect on many sufferers, especially in cases of mild to moderate depression.